Beneficial effects of HCQ and Zinc against COVID-19

The key is preventing infection and stopping post exposure viral loading through effective prophylactic treatment.

“Chloroquine interferes with a virus' ability to replicate in two ways – it alters the pH levels of the endosomes, compartments that the virus enters, and prevents the virus from plugging into the ACE2 receptors.”

1- Reduces acidity of cell walls which inhibits endocytosis, the process of viral membrane fusion to ACE2 receptors, and limits spike protein cleavage. HCQ also alters glycosylation of ACE2 and sialic acid receptors, inhibiting the virus from binding to these points.

2- HCQ is able to inhibit viral RNA replication and repackaging functions inside cells by decreasing the acidity of the cytoplasmic environment and in organelles such as the endoplasmic reticulum and the golgi apparatus which the virus uses to replicate. 

3- HCQ is an effective zinc ionophore which creates passageways for Zinc to enter cells. Zinc, acting as an antiviral agent, is able to effectively block virus RDRP (RNA-dependent RNA polymerase) replication and decreases the virus’s ability to grow and be transm…